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Linking cell biology and ecology to understand coral symbiosis evolution

Niels J. Dingemanse, Annika Guse

PLOS Biology, April 2024,

Negative phototaxis in the photosymbiotic sea anemone Aiptasia as a potential strategy to protect symbionts from photodamage
Kishimoto, M., Gornik, S.G., Foulkes, N.S., Guse, A.
Scientific Reports, Oct 2023,

Unlocking the Complex Cell Biology of Coral-Dinoflagellate Symbiosis: A Model Systems Approach

Jacobovitz, M.R., Hambleton, E. A., Guse, A.
Annual Review of Genetics, 2023 Sep, doi:10.1146/annurev-genet-072320-125436

A predatory gastrula leads to symbiosis-independent settlement in Aiptasia
Maegele, I., Rupp, S., Özbek, S., Guse, A., Hambleton, E. A., Holstein, T.W.
PNAS, 2023 Sep, doi:10.1073/pnas.2311872120

Host nutrient sensing is mediated by mTOR signaling in cnidarian-dinoflagellate symbiosis
Voss, P.A., Gornik, S.G., Jacobovitz, M.R., Rupp, S., Dörr, M., Maegele, I., Guse, A.
Current Biology, 2023 Sep, doi:10.1016/j.cub.2023.07.038

Nuclear transformation of a dinoflagellate symbiont of corals 
Gornik, S.G., Maegele, I., Hambleton, E.A., Voss, P.A., Ross F. Waller, R.F. and Guse, A.
Frontiers in Marine Science, 2022 Nov, doi:10.3389/fmars.2022.1035413

Dinoflagellate symbionts escape vomocytosis by host cell immune suppression
Jacobovitz, M.R.*, Rupp, S.*, Voss, P.A., Maegele, I., Gornik, S.G, Guse, A. (*equal contribution)
Nature Microbiology, 2021 Apr, doi:10.1038/s41564-021-00897-w Full text access (pdf)

Photoreceptor diversification accompanies the evolution of Anthozoa
Gornik, S.G., Bergheim, B.G., Morel, B., Stamatakis, A., Foulkes, N.S., Guse, A.
Molecular Biology and Evolution, 2020 Nov, doi:/10.1093/molbev/msaa304

Sterol transfer by atypical cholesterol-binding NPC2 proteins in coral-algal symbiosis
Hambleton, E.A., Jones, V.A.S., Maegele, I., Kvaskoff, D. Sachsenheimer, T., Guse, A.
eLife, 2019 Jun, 10.7554/eLife.43923

Microinjection to deliver protein, mRNA and DNA into zygotes of thecnidarian endosymbiosis model
Aiptasia sp.

Jones, V.A.S.*, Bucher, M.*, Hambleton, E.A., Guse, A.
Scientific Reports, 2018 Nov, doi:10.1038/s41598-018-34773-1

Aiptasia sp. larvae as a model to reveal mechanisms of symbiont selection in cnidarians.
Wolfowicz, I., *Baumgarten, S.,*Voss, P.A., Hambleton, E.A., Voolstra, C.R., Hatta, M., Guse, A.
Scientific Reports, 2016 Sep, doi:10.1038/srep32366

Development and symbiosis establishment in the cnidarian endosymbiosis model Aiptasia sp..
Bucher, M., Wolfowicz, I., Voss, P.A., Hambleton, E.A., Bucher, M., Guse, A.
Scientific Reports, 2016 Jan, doi:10.1038/srep19867

Induction of gametogenesis in the cnidarian endosymbiosis model Aiptasia sp..
Grawunder, D.*, Hambleton, E.A.*, Bucher, M., Wolfowicz, I., Bechtoldt, N., Guse, A.
Scientific Reports, 2015 Oct, doi:10.1038/srep15677

The genome of Aiptasia, a sea anemone model for coral symbiosis.
Baumgarten, S., Simakov, O., Esherick, L.Y., Liew,Y.J., Lehnert,E.M., Michell, C.T, Li, Y., Hambleton, E.A, Guse, A., Oates, M.E., Gough, J., Weis, V.M., Aranda, M., Pringle, J.R., Voolstra, C.R.
PNAS, 2015 Aug, 11893–11898, doi: 10.1073/pnas.1513318112

Similar specificities of symbiont uptake by adults and larvae in an anemone model system for coral biology.
Hambleton, E.A.*, Guse, A.*, Pringle, J.R.
Journal of Experimental Biology, 2014 May 1;217 (1613-1619)
[PMID: 24526722]

CENP-A confers a reduction in height on octameric nucleosomes.
Miell, M.D.D, Fuller, C.J., Guse, A., Barysz, H.M., Downes, A., Owen-Hughes, T., Rappsilber, J., Straight, A.F., Allshire, R.C.
Nature Structure & Molecular Biology, 2013 Jun;20(6):763-5
[PMID: 23644598]

A cell free system for functional centromere and kinetochore assembly.
Guse, A., Fuller, C.J., Straight, A.F.
Nature Protocols 2012 Sep 20;7 (1847-1869)
[PMID: 23018190]

In vitro centromere and kinetochore assembly on defined chromatin templates.
Guse, A., Carroll, C.W., Moree, B., Fuller, C.J., Straight, A.F.
Nature 2011 Aug 28;477(7364):354-8
[PMID: 21874020]

Functional knockdown of VCAM-1 at the posttranslational level with ER retained antibodies.
Strebe, N.*, Guse, A.*, Schüngel, M., Schirrmann, T., Hafner, M., Jostock, T., Hust, M., Müller, W., Dübel, S.
Journal of Immunological Methods 2009 Feb 28;341(1-2):30-40
[PMID: 19038261]

Phosphorylation of ZEN-4/MKLP1 by aurora B regulates completion of cytokinesis.
Guse, A., Mishima, M., Glotzer, M.
Current Biology 2005 Apr 26;15(8):778-86
[PMID: 15854913]

CSC-1: a subunit of the Aurora B kinase complex that binds the survivin-like protein BIR-1 and the incenp-like protein ICP-1.
Romano, A., Guse, A., Krascenicova, I., Schnabel, H., Schnabel, R., Glotzer, M.
Journal of Cell Biology 2003 Apr 28;161(2):229-36
[PMID: 12707312]

Biochemical and structural analysis of the molybdenum cofactor biosynthesis protein MobA.
Guse, A., Stevenson, C.E., Kuper, J., Buchanan, G., Schwarz, G., Giordano, G., Magalon, A.,Mendel, R.R., Lawson, D.M., Palmer, T.
Journal of Biological Chemistry 2003 Jul 11;278(28):25302-7
[PMID: 12719427]


Current Research

Shedding light on corals: How DNA damage repair, the circadian clock and cryptochromes shape the response of Anthozoa to sunlight

Principal Investigators: Annika Guse & Nicolas Foulkes

Funding Organization: German Research Foundation (DFG)

Project Number:  50844158 

Funding: 467.500 €

Previous Projects
Organization and function of the dinoflagellate genome

Principal Investigators: Stephanie Weber, Aaron Straight and Annika Guse

Duration: 2020 - 2022 

Funding Organisation: New Frontiers in Research Fund - Exploration

Project Number: NFRFE-2019-00189

Funding: 250.000$

Mensch & Meer: symbiotische Lebensformen verstehen und vermitteln 

Principal Investigators: Annika Guse & Nikolas Jaspert

Duration: 01/10/2020 - 31/03/2022

Funding Organisation: Heidelberg University 

Grant Type: Marsilius Kolleg Fellows

Funding: 80.000€

Resolving the molecular mechanisms of intracellular coral-algal symbiosis (SYMCELLS)

Principal Investigator: Annika Guse

Duration: 01/06/2017 to 31/05/2022

Funding organization: European Research Council 

Project Number: 724715

Funding: 2.270.500€ 

Cholesterol-binding proteins and dinoflagellate sterols in coral symbiosis

Principal Investigator: Annika Guse

Duration: 01/06/2016 - 31/05/2017

Funding Organization: Boehringer Ingelheim Stiftung 

Grant Type: Exploration Grant

Funding: 72.650 €

Molecular Basis of Coral Symbiosis (ESYMBIOSIS)

Principal Investigator: Annika Guse

Duration: 01/05/2014 to 30/04/2018

Funding Organization: European Commission 

Project Number:  631740

Funding: 100.000€

Molecular basis of cnidarian endosymbiosis and its response to environmental change 

Principal Investigator: Annika Guse

Duration: 01/01/2013 to 31/12/2017

Funding Organization: German Research Foundation (DFG) 

Project Number: 221467980

Funding: 1.670.000€

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